The development of new therapeutics targeting protein kinases is crucial in the fight against diseases like cancer.
Regulating protein activity through addition and removal of phosphate groups is an abiding feature of metazoan life. Essentially all physiologic processes are directly affected by the phosphorylation ...
Kinases catalyze the transfer of the γ-phosphate from adenosine 5´-triphosphate (ATP) to proteins, lipids, sugars, or other acceptors. This process, termed phosphorylation, forms the cornerstone of ...
Cells contain a large number of antioxidants to prevent or repair the damage caused by reactive oxygen species, as well as to regulate redox-sensitive signaling pathways. General protocols are ...
The new Transcreener cGAMP cGAS Assay directly measures the product cGAMP, in a cGAS enzymatic reaction allowing researchers to screen vast compound libraries for modulators of the enzyme. The assay ...
The last two decades have witnessed the steady growth of the protein drug market. As original recombinant products come off patent, generics/ biosimilars are also beginning to be manufactured. The ...
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