Allergic diseases represent a major global health burden, placing significant strain on health care systems worldwide. Severe ...

Basophils, though the rarest granulocytes, have emerged as pivotal modulators of immune responses in both allergic inflammation and autoimmunity. These cells are now recognised for their ability to ...

C. Ohnmacht et al., “Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths,” Immunity, 33:364-74, 2010. Free F1000 Evaluation Basophils were deemed critical in ...

Researchers discovered Fab antibody fragments that target the IgE Cε2 domain, destabilizing IgE–FcεRI complexes on mast cells. In mouse models, allergic responses were significantly reduced. This ...