Researchers have simplified the operation of an important class of chemical transformation: synthesis of beta-lactams, the intricate scaffold of many antibiotics. Their experimental protocol minimizes ...

Researchers have made a significant breakthrough in the field of asymmetric synthesis of beta-lactams, which are prominent in bioactive compounds. Their innovative approach employs nickel and ...

A carbapenem molecule, a last resort antibiotic, enters the carbapenemase enzyme (blue arrow), where the crucial beta-lactam structure gets broken down. The ineffective molecule then leaves (orange ...

Osaka, Japan – While we appear to live in a world of plenty, behind the scenes, sourcing sufficient amounts of key ingredients can be challenging. For example, the synthesis of certain antibiotics, ...