A new in vivo pharmacokinetic recall study involving 114 participants in the Estonian Biobank has provided the first clinical ...
Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined ...
In recent years, scientists discovered that an enzyme called CYP2D6 could possibly predict whether a patient would respond to the drug. Small studies aimed at confirming the predictive link, however, ...
A study based on data from the Estonian Biobank shows that previously unstudied genetic variants may slow the breakdown of medications, leading to their buildup in the body. The risk of side effects ...
Aim We sought to discover endogenous urinary biomarkers of human CYP2D6 activity. Patients & Methods Healthy pediatric subjects (n = 189) were phenotyped using dextromethorphan and randomized for ...
Recent advances in oligonucleotide microarray technology (“gene chips”) permit rapid screening for DNA sequence variation. The CYP2D6 gene encodes debrisoquine hydroxylase, which metabolizes the ...
Credit: Shutterstock. According to HF guidelines, beta-blockers must be titrated to a specific target dose in order to obtain their morbidity and mortality benefit in HF patients. According to a ...
December 10, 2010 (San Antonio, Texas) — New analyses of data from 2 large trials have found no association between the CYP2D6 genotype and the effectiveness of tamoxifen in preventing breast cancer ...
—New research uncovers a possible link between CYP2D6 activity and the development of tardive dyskinesia in certain patients taking antipsychotics. Reviewed by Nicole Foubister, Clinical Assistant ...
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