Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture. The cohesin complex dynamically restructures ...
Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct the complex dynamics of how cells decide their fate. As reported in Nature ...
The development of humans and other animals unfolds gradually over time, with cells taking on specific roles and functions ...
Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is ...
Stem cells have great applications in regenerative medicine. While transcription factors traditionally dominate fate determination research, recent 3D genomics reveals chromatin topology’s critical ...
Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH ...
The diagram depicts negative feedback mechanisms via IκB proteins and A20 in the canonical pathway, and IKKα onto NIK in the non-canonical pathway. There are cross-talk mechanisms such as NIK ...
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