The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...
From rare cancers caught early to dementia foretold decades in advance, newborn genomic testing raises an unsettling question ...
An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene ...
Modern crop breeding is entering a new era of genome design, led by genome editing technologies as mainstream tools for targeted genome modification. In a review published in Nature Reviews Genetics, ...
A new liquid biopsy developed by researchers at the University of Chicago is offering a powerful new window into cancer’s earliest stages by flagging subtle shifts in the gut microbiome. Unlike ...
A new study has created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models ...
The prime editor is a fusion protein consisting of a catalytically impaired Cas9 nickase (Cas9n) and an engineered reverse transcriptase (RT). The Cas9n is guided by a prime editing guide RNA (pegRNA) ...
This image depicts the chemical structure of cytosine. It shows a hexagonal ring with nitrogen atoms at positions 1 and 3, and a primary amine group attached to carbon 4. The two remaining positions ...
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