Schizophrenia-linked genetic variant renders brain receptor unresponsive to both natural and therapeutic compounds

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely ...
News-Medical.Net on MSN

TAAR1 mutation impairs brain signaling in schizophrenia

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely ...
eLife

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...
eLife

Separating selection from mutation in antibody language models

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...
The New England Journal of Medicine

Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein ...