New method reveals how mutations drive transthyretin amyloidosis and guides precision drug design

An international research team reveals new molecular mechanisms associated with pathogenic mutations in the protein ...
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Menopausal hormone therapy may not pose breast cancer risk for women with BRCA mutations, analysis suggests

Using menopausal hormone therapy (MHT) was not associated with an increased risk of breast cancer in women with inherited mutations in the BRCA1 or BRCA2 genes, according to the results of a matched ...
EurekAlert!

Integrative scATAC-seq and mtDNA mutation analysis reveals disease-driven regulatory aberrations in AML

Disruptions in transcriptional regulation during hematopoiesis can lead to abnormal hematopoietic differentiation and the development of leukemia. Understanding the underlying mechanisms of disease ...
ascopubs.org

Analysis of ATM germline mutations in solid tumors from Chinese patients.

Twenty-one gene recurrence scores in individuals with breast cancer associated with CHEK2 and ATM germline pathogenic variants. Characteristics and clinical outcome of BRCA germline mutation carriers ...
News Medical on MSN

Advances in liquid biopsies as a tool for detecting lung cancer mutations

Researchers used a panel to assess the presence of circulating tumor DNA in plasma samples and detected changes in genes related to the development of adenocarcinoma that indicated both actionability ...