The traditional view of tau is that of a rather dull microtubule-binding protein that occasionally goes rogue, wandering off into other cellular compartments where it stokes neurodegeneration. At ...

In Alzheimer's Disease and other neurodegenerative dementias, proteins that normally play a role in healthy brain tissue turn bad, clumping together to form insoluble plaques and tangles as neurons ...

In Alzheimer’s Disease and other neurodegenerative dementias, proteins that normally play a role in healthy brain tissue turn bad, clumping together to form insoluble plaques and tangles as neurons ...

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the “tau interactome” uncovering new findings about the role of tau in neurodegenerative disease.

Tauopathies are classified by which tau isoform forms fibrils—those with three microtubule-binding domain repeats (3R), those with four (4R), or those with both. What drives one isoform to aggregate ...

A review published in Genomic Psychiatry by Dr. Peng Lei and colleagues presents a sweeping synthesis of tau protein research that fundamentally reframes our understanding of this molecule's dual ...

Newly reported research headed by a team at the Perelman School of Medicine at the University of Pennsylvania points to a potential gene therapy approach to neurodegenerative disorders characterized ...