Crypt-base-columnar cells are continuously dividing intestinal stem cells that generate IECs, which are composed by distinct specialised cell types that play different functions: Enterocytes (in the ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system. To maintain ...

Unfolded peptides and proteins exhibit a remarkable degree of structural diversity that defies the notion of a simple random coil. Recent investigations have elucidated that even in their so-called ...

Drugs that interrupt the death of healthy bone cells and induce the death of cancerous cells located in bones can prevent or reduced cancer associated bone weakness and improve treatment outcomes for ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions.