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0:18
YouTube
Cell Press
Visualizing early steps in endosomal maturation
Internalization of cell surface receptors is followed by their transport to endosomes. A subpopulation of endosomes defined by the presence of the protein APPL, a Rab 5 effector, has a specialized role in propagating signaling of internalized receptors. Here, macropinosomes (arrowheads) generated from membrane ruffles and marked by PI3P (green ...
1.2K views
Dec 7, 2018
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