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Grapefruit can alter how certain medications work because it contains natural compounds called furanocoumarins, which interfere with enzymes in the small intestine—specifically CYP3A4. These enzymes normally help break down many drugs before they enter the bloodstream. When grapefruit blocks this enzyme, the medication can enter the body in higher concentrations than intended, increasing the risk of side effects or toxicity. In some cases, grapefruit can also affect drug transporters that move m
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